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Thermo Scientific Chemicals
Niflumic acid, 99+%
CAS: 4394-00-7 | C13H9F3N2O2 | 282.22 g/mol
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化学标识符
CAS4394-00-7
IUPAC Name2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid
Molecular FormulaC13H9F3N2O2
InChI KeyJZFPYUNJRRFVQU-UHFFFAOYSA-N
SMILESOC(=O)C1=CC=CN=C1NC1=CC=CC(=C1)C(F)(F)F
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规格表It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
Solubility
Soluble in ethanol (∼50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (∼50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (∼50 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Hygroscopic. Keep away fom strong oxidizing agents.
It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
Solubility
Soluble in ethanol (∼50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (∼50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (∼50 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Hygroscopic. Keep away fom strong oxidizing agents.
RUO – Research Use Only
General References:
- Ottolia .; Toro. Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 1994, 67 ,(6), 2272-9.
- Famaey. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 1997, 46 ,(11), 437-46.