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苏拉明钠
Suramin hexasodium salt (suramin sodium, CAS # 129-46-4) is the sodium salt of suramin. | CAS: 129-46-4 | C51H34N6Na6O23S6 | 1429.15 g/mol
| 货号 | 数量 |
|---|---|
| J61707.MD 又称 J61707-MD | 250 mg |
规格
Beilstein3694087
CAS129-46-4
化学名称或材料Suramin hexasodium salt
颜色White
EINECS 编号204-949-3
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Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF. It is used as a G protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5. It also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Suramin is a polysulphonated napthylurea which exhibits anti-parasitic and anticancer properties
• Suramin prevents endothelial cell migration and proliferation through inhibition of IGF-I, EGF, PDGF, and TGF-beta
• Suramin can also uncouple G-proteins from receptors and turn off cell signaling cascades
Application
• Suramin inhibits angiogenesis through blockade of bFGF and VEGF and can be useful for the laboratory study of blood vessel growth and renewal following injury
• Suramin inhibits DNA topoisomerases, and can be used as an antineoplastic agent in the laboratory study of cancer or for studies of microbial physiology
RUO – Research Use Only
General References:
- Xiong C, Liu N, Shao X, Sharif S, Zou H, Zhuang S. Delayed administration of suramin attenuates peritoneal fibrosis in rats. BMC Nephrol. 2019 Nov 14;20(1):411. doi: 10.1186/s12882-019-1597-2. PMID: 31727005; PMCID: PMC6854809
- Tan CW, Sam IC, Chong WL, Lee VS, Chan YF. Polysulfonate suramin inhibits Zika virus infection. Antiviral Res. 2017 Jul;143:186-194. doi: 10.1016/j.antiviral.2017.04.017. Epub 2017 Apr 27. PMID: 28457855.