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Thermo Scientific Chemicals
Capsazepine, 98+%
A competitive antagonist for capsaicin and resiniferatoxin | CAS: 138977-28-3 | C19H21ClN2O2S | 376.899 g/mol
| 货号 | 数量 |
|---|---|
| J63055.MF 又称 J63055-MF | 50 mg |
化学标识符
CAS138977-28-3
IUPAC NameN-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-2-benzazepine-2-carbothioamide
Molecular FormulaC19H21ClN2O2S
InChI KeyDRCMAZOSEIMCHM-UHFFFAOYSA-N
SMILESOC1=CC2=C(CN(CCC2)C(=S)NCCC2=CC=C(Cl)C=C2)C=C1O
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规格
规格表
规格表Appearance (Color)Powder
FormPale cream to cream
Proton NMRConforms to structure
Assay (HPLC)≥ 98.0%
Solution TestSoluble in DMSO at 100mM
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.
Solubility
Soluble in ethanol or DMSO
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.
Solubility
Soluble in ethanol or DMSO
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Dickenson and Dray. Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br.J.Pharmacol. 1991, 104, (4), 1045-9.
- Kwak et al. A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience. 1998, 86, (2), 619-26.