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Thermo Scientific Chemicals
Naringin
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activity | CAS: 10236-47-2 | C27H32O14 | 580.54 g/mol
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化学标识符
CAS10236-47-2
IUPAC Name(2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
Molecular FormulaC27H32O14
InChI KeyDFPMSGMNTNDNHN-ZPHOTFPESA-N
SMILESC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC2=CC(O)=C3C(=O)C[C@H](OC3=C2)C2=CC=C(O)C=C2)[C@H](O)[C@H](O)[C@H]1O
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规格
规格表
规格表Assay from Supplier's CofA≥95.0% (HPLC)
FormPowder
Loss on Drying≤6.0%
Appearance (Color)Pale to dark cream
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer′s disease.
Solubility
Soluble in water, alcohol, acetone and warm acetic acid.
Notes
Incompatible with strong oxidizing agents.
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer′s disease.
Solubility
Soluble in water, alcohol, acetone and warm acetic acid.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Nguyen, M. A.; Staubach, P.; Tamai, I.; Langguth, P. High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. Eur. J. Pharm. Sci. 2015, 68, 36-42.
- Pai, D. A.; Vangala, V. R.; Ng, J. W.; Ng, W. K.; Tan, R. B. H. Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization. J. Food Eng. 2015, 161, 68-74.