Cyclosporin A, 99+%
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Cyclosporin A, 99+%
Cyclosporin A, 99+%
Cyclosporin A, 99+%
Thermo Scientific Chemicals

Cyclosporin A, 99+%

Cyclosporin A, CAS # 59865-13-3, is a compound that shows immunosuppressive, antifungal, antirheumatic, and dermatologic activities. It is also a calcineurin and enzyme inhibitor. | CAS: 59865-13-3 | C62H111N11O12 | 1202.64 g/mol
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数量:
1 g
5 g
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货号 J63191.06
又称 J63191-06
价格（CNY)
-
数量:
5 g
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化学标识符
CAS59865-13-3
规格Specification Sheet规格表
Appearance (Color)White
Assay from Suppliers CofA≥99.0%
FormPowder or crystals or crystalline powder
Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum

Applications

  • It inhibits phosphoprotein phosphatase
  • Cyclosporin A binds to the cellular protein cytophilin and inhibits the enzyme calcineurin
  • Furthermore, it can induce apoptosis and inhibit angiogenesis induced by VEGF
  • It exerts potent immunosuppressive activity on T immune cells, and causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle
  • It also suppresses the hepatitis C virus replication in cultured hepatocytes
RUO – Research Use Only

General References:

  1. Staudinger, L. A.; Spano, S. J.; Lee, W. S.; Coelho, N.; Moriarty, T. J.; McCulloch, C. A. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A. Int. J. Biochem. Cell Biol. 2015, 62, 80-87.
  2. Petrillo, C.; Cesana, D.; Piras, F.; Bartolaccini, S.; Naldini, L.; Montini, E.; Rudnitski, A. K. Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells. Molecular Therapy 2015, 23 (2), 352-362.