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Dizocilpine maleate, 99+%
NMDA receptor antagonist that prevents calcium flux | CAS: 77086-22-7 | C20H19NO4 | 337.375 g/mol
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化学标识符
CAS77086-22-7
IUPAC Name(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0²,⁷.0¹⁰,¹⁵]hexadeca-2,4,6,10,12,14-hexaene; (2Z)-but-2-enedioic acid
Molecular FormulaC20H19NO4
InChI KeyQLTXKCWMEZIHBJ-PJGJYSAQSA-N
SMILESOC(=O)C=C/C(O)=O.C[C@]12N[C@H](CC3=CC=CC=C13)C1=CC=CC=C21
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规格表Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
Solubility
Soluble in ethanol.
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
Solubility
Soluble in ethanol.
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
RUO – Research Use Only
General References:
- Lannes, B.; Bernard, V.; Bloch, B.; Micheletti, G. Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene. Neuroscience. 1995, 65, (2), 431-438.
- Salin, P.; Nieoullon, A.; Kerkerian-Le Goff, L. Reversal of the adaptive response of neuropeptide Y neurons in the rat striatum to nigrostriatal dopamine deafferentation by theN-methyl-d-aspartate antagonist dizocilpine maleate. Neuroscience. 1994, 61, (1), 93-105.