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Thermo Scientific Chemicals
D-Mannosamine hydrochloride, 98%
CAS: 5505-63-5 | C6H14ClNO5 | 215.63 g/mol
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化学标识符
CAS5505-63-5
IUPAC Namehydrogen (2S,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanoic acid chloride
Molecular FormulaC6H14ClNO6
InChI KeyJMVMHPCPPSZGNY-BZWNWTOPSA-N
SMILES[H+].[Cl-].N[C@@H]([C@@H](O)[C@H](O)[C@H](O)CO)C(O)=O
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规格
规格表
规格表Appearance (Color)White to off-white
Assay (HPLC)97.5% min.
Residue on ignition0.5% max.
Loss on Drying0.5% max.
FormPowder
D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer's patches.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer′s patches.
Solubility
Soluble in water and methanol.
Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.
D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer′s patches.
Solubility
Soluble in water and methanol.
Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Kim, S. J.; Cho, H. Convenient Synthesis of Glucosamine and Mannosamine Starting from Glucose. Bull. Korean Chem. Soc. 2015, 36 (7), 1916-1918.
- Planas, O.; Bresolí-Obach, R.; Nos, J.; Gallavardin, T.; Ruiz-González, R.; Agut, M.; Nonell, S. Synthesis, Photophysical Characterization, and Photoinduced Antibacterial Activity of Methylene Blue-loaded Amino-and Mannose-Targeted Mesoporous Silica Nanoparticles. Molecules 2015, 20 (4), 6284-6298.