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乳酸甲氧苄啶
Trimethoprim, CAS # 738-70-5, is a trimethoxybenzyl-pyrimidine used as an antimicrobial. | CAS: 23256-42-0 | C17H24N4O6 | 380.401 g/mol
| 货号 | 数量 | 包装 |
|---|---|---|
| J66646.MD | 250 mg | Plastic Bottle |
化学标识符
CAS23256-42-0
IUPAC Name2-hydroxypropanoic acid; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Molecular FormulaC17H24N4O6
InChI KeyIIZVTUWSIKTFKO-UHFFFAOYNA-N
SMILESCC(O)C(O)=O.COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC
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规格
规格表
规格表Assay (unspecified)97.5% min.
A broad spectrum antibiotic
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced
• Trimethoprim has antibacterial and antiprotozoal properties
Applications
• Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects
• Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression
RUO – Research Use Only
General References:
- De Smet, J.; Croubels, S.; De Backer, P.; Devreese, M. Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs. Int J Antimicrob Agents. 2017, 50(6), 707-714.
- Ma, R.; Wang, Y.; Zou, X.; Hu, K.; Sun, B.; Fang, W.; Fu G, Yang X. Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose. Environ Toxicol Pharmacol. 2017, 52, 90-98.