Profiling antibody responses by multiparametric analysis of primary B cells.
Authors:Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, Love JC,
Journal:Proc Natl Acad Sci U S A
PubMed ID:19004776
'Determining the efficacy of a vaccine generally relies on measuring neutralizing antibodies in sera. This measure cannot elucidate the mechanisms responsible for the development of immunological memory at the cellular level, however. Quantitative profiles that detail the cellular origin, extent, and diversity of the humoral (antibody-based) immune response would improve ... More