抑胃肽 A，BODIPY™ FL 偶联物
抑胃肽 A，BODIPY™ FL 偶联物
引用和文献 (16)
Invitrogen™

抑胃肽 A，BODIPY™ FL 偶联物

对于通过荧光显微镜检查对细胞蛋白酶 D 运输进行的研究，请尝试使用我们的 BODIPY FL 抑胃肽 A。这种绿色荧光探针可以抑制体外组织蛋白酶 D (IC50了解更多信息
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货号数量
P1227125 μg
货号 P12271
价格（CNY)
3,001.00
Online Exclusive
Ends: 31-Dec-2026
4,168.00
共减 1,167.00 (28%)
Each
添加至购物车
数量:
25 μg
价格（CNY)
3,001.00
Online Exclusive
Ends: 31-Dec-2026
4,168.00
共减 1,167.00 (28%)
Each
添加至购物车
对于通过荧光显微镜检查对细胞蛋白酶 D 运输进行的研究，请尝试使用我们的 BODIPY FL 抑胃肽 A。这种绿色荧光探针可以抑制体外组织蛋白酶 D (IC50 ∼50 nM)，靶向活细胞溶酶体内组织蛋白酶 D。这一新探针研究的初步结果表明，它可通过内吞途径运输至活细胞的溶酶体，并且可由未标记的抑胃肽 A 竞争置换。
仅供科研使用。不可用于诊断程序。
规格
产品线BODIPY
数量25 μg
建议的储存条件在冷冻冰箱（-5°C 至 -30°C）中避光储存。
运输条件室温
物理形态实心
产品类型抑胃肽 A
Unit SizeEach

引用和文献 (16)

引用和文献
Abstract
Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases.
Authors:Yang DS, Lee JH, Nixon RA,
Journal:Methods Enzymol
PubMed ID:19216904
'This chapter describes detailed methods to monitor autophagy in neurodegenerative disorders, especially in Alzheimer''s disease. Strategies to assess the competence of autophagy-related mechanisms in disease states ideally incorporate analyses of human disease and control tissues, which may include brain, fibroblasts, or other peripheral cells, in addition to animal and cell ... More
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
Authors:Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA,
Journal:J Neurosci
PubMed ID:18596167
'Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer''s disease (AD). The basis for the profuse accumulation of autophagic vacuoles (AVs) in affected neurons of the AD brain, however, is unknown. In this study, we show that constitutive macroautophagy in primary cortical ... More
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Authors:Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA,
Journal:Cell
PubMed ID:20541250
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result ... More
Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.
Authors:Raiber EA, Tulone C, Zhang Y, Martinez-Pomares L, Steed E, Sponaas AM, Langhorne J, Noursadeghi M, Chain BM, Tabor AB,
Journal:ACS Chem Biol
PubMed ID:20349916
Improved chemical inhibitors are required to dissect the role of specific antigen processing enzymes and to complement genetic models. In this study we explore the in vitro and in vivo properties of a novel class of targeted inhibitor of aspartic proteinases, in which pepstatin is coupled to mannosylated albumin (MPC6), ... More
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.
Authors:Gerasimenko JV, Sherwood M, Tepikin AV, Petersen OH, Gerasimenko OV
Journal:J Cell Sci
PubMed ID:16410548
Inositol trisphosphate and cyclic ADP-ribose release Ca2+ from the endoplasmic reticulum via inositol trisphosphate and ryanodine receptors, respectively. By contrast, nicotinic acid adenine dinucleotide phosphate may activate a novel Ca2+ channel in an acid compartment. We show, in two-photon permeabilized pancreatic acinar cells, that the three messengers tested could each ... More
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