A part of the PI3K/AKT Pathway, 4E-BP1 (EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1) is a cytosolic protein that is phosphorylated at Thr46 by mTORC1 upon stimulation of the pathway.
For use in combination with the GFP-4E-BP1 physiological protein substrate (PV4759) to evaluate inhibitors in medium to high throughput screening applications. An optimized mTor assay buffer (PV4794) is also available.
For Research Use Only. Not for use in diagnostic procedures.
规格
偶联物
Tb (Terbium)/GFP (EmGFP)
产品规格
384-well Plate
激发/发射
340⁄490, 520
反应性
Human
运输条件
Dry Ice
读值
End Point
反应性 abrv
Hu
目标酶
Serine⁄Threonine Kinases
技术
TR-FRET
已验证激酶
FRAP1 (mTOR), FRAP1 (mTOR)
产品线
LanthaScreen™
内容与储存
Terbium-labeled anti-4E-BP1 [pThr46] antibody in HEPES buffered saline. Store at -20°C.