ERM (LRRKtide) 底物
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引用和文献 (1)

ERM (LRRKtide) 底物

A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™了解更多信息
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货号数量
PV50931 mL
货号 PV5093
价格（CNY)
15,787.00
Each
添加至购物车
数量:
1 mL
价格（CNY)
15,787.00
Each
添加至购物车
A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™ Universal Kinase Assay (PV5099).
仅供科研使用。不可用于诊断程序。
规格
氨基酸序列RLGRDKYKTLRQIRQ
检测条目生化 ADP 积聚
基因 ID (Entrez)120892
分子量1931.2 Da
数量1 mL
运输条件干冰
底物基于埃兹蛋白/根蛋白/膜突蛋白 (ERM) 的肽
目标条目LRRK2 G2019S、LRRK2
已验证激酶LRRK2
检测方法荧光
底物属性基于肽的底物
底物类型激酶底物
目标酶丝氨酸/苏氨酸激酶
Unit SizeEach
内容与储存
2 mM ERM (LRRKtide) 肽底物，溶于 50 mM HEPES（pH 值 7.5）、0.01% Brij-35、10 mM MgCl2 和 1 mM EGTA。储存在 -20°C 下。

引用和文献 (1)

引用和文献
Abstract
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Authors:Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B,
Journal:FEBS J
PubMed ID:19076219
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and ... More