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引用和文献 (163)
Invitrogen™
琥珀酰亚胺 3-(2-吡啶基二硫基)丙酸酯 (SPDP)
The heterobifunctional, crossslinker succinimidyl 3-(2-pyridyldithio)propionate (SPDP) enables one to covalently link two target groups. The succinimidyl ester chemically reacts with了解更多信息
| 货号 | 数量 |
|---|---|
| S1531 | 100 mg |
货号 S1531
价格（CNY)
4,119.00
飞享价
Ends: 31-Dec-2025
5,216.00共减 1,097.00 (21%)
Each
数量:
100 mg
价格（CNY)
4,119.00
飞享价
Ends: 31-Dec-2025
5,216.00共减 1,097.00 (21%)
Each
The heterobifunctional, crossslinker succinimidyl 3-(2-pyridyldithio)propionate (SPDP) enables one to covalently link two target groups. The succinimidyl ester chemically reacts with primary amines and after mild reduction of the dithiol, it can react form a disulfide with other thiols. Crosslinking reagents are useful for probing the spatial relationships and interactions within and between biomolecules.
仅供科研使用。不可用于诊断程序。
规格
细胞渗透性是
描述SPDP
形式实心
标记方法化学标记
分子量312.36
聚乙二醇化否
数量100 mg
反应一部分NHS 酯、吡啶二硫化物
溶解度DMF、DMSO
间隔臂长6.8 Å
水溶性否
化学反应性胺-巯基
可裂解用硫醇
交联剂类型异型双功能团试剂
产品规格标准
产品类型交联剂
间隔子短 (<10 Å)
Unit SizeEach
内容与储存
收到后，在 -20°C 下避光储存。
常见问题解答 (FAQ)
Can you provide the shelf-life for Succinimidyl 3-(2-Pyridyldithio)Propionate (SPDP)?
引用和文献 (163)
引用和文献
Abstract
Blockade of the galactose-binding sites of ricin by its linkage to antibody. Specific cytotoxic effects of the conjugates.
Journal:European journal of biochemistry
PubMed ID:6608447
A method is described for preparing specific cytotoxic agents by linking intact ricin to antibodies in a manner that produces obstruction of the galactose-binding sites on the B chain of the toxin and so diminishes the capacity of the conjugate to bind non-specifically to cells. The conjugates were synthesised by
Enhancement of the thrombolytic potency of plasminogen activators by conjugation with clot-specific monoclonal antibodies.
Journal:Bioconjug Chem
PubMed ID:1790167
Detection of one attomole of [Arg8]-vasopressin by novel noncompetitive enzyme immunoassay (hetero-two-site complex transfer enzyme immunoassay).
Journal:J Biochem (Tokyo)
PubMed ID:1778973
'One attomole of [Arg8]-vasopressin (AVP) was detected by a novel noncompetitive enzyme immunoassay (hetero-two-site complex transfer enzyme immunoassay). AVP was indirectly biotinylated using N-hydroxysuccinimidobiotin and trapped onto an anti-AVP IgG-coated polystyrene ball. After washing, biotinylated AVP was eluted from the polystyrene ball with HCl and was reacted with 2,4-dinitrophenyl-fluorescein disulfide-bovine
Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.
Journal:Biochemistry
PubMed ID:1731945
'Carboxypeptidase A (CP-A) and monoclonal antibody KS1/4 directed against an antigen on human lung adenocarcinoma cells (UCLA-P3) were derivatized by treatment with succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate and N-succinimidyl 3-(2-pyridyldithio)propionate, respectively. The derivatized proteins were reacted to produce thioether-linked enzyme-antibody conjugates. Sequential HPLC size-exclusion and DEAE chromatography separated the conjugate preparation from unreacted
Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor.
Journal:J Cell Biol
PubMed ID:2993314
'A hybrid toxin composed of ricin A chain and a monoclonal antibody directed against the rat nerve growth factor (NGF) receptor (192-IgG) was prepared using the heterobifunctional cross-linking agent N-succinimidyl-3-(2-pyridyldithio)-propionate and purified by affinity chromatography. Characterization studies showed that the hybrid, 192-s-s-A, displaced bound 125I-labeled 192-IgG from rat superior cervical