毒胡萝卜素
毒胡萝卜素
引用和文献 (508)
Invitrogen™

毒胡萝卜素

毒胡萝卜素是从伞形科植物Thapsia garganica分离得到的一种天然倍半萜内酯。这种肿瘤启动子会通过特异性抑制内质网 Ca2+-ATP 酶释放细胞内储存的 Ca2+；它不会直接影响细胞膜 Ca2+ATP 酶、Ins 1,4,5-P3了解更多信息
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货号数量
T74581 mg
T745920 x 50 μg
货号 T7458
价格（CNY)
2,392.00
1 mg
添加至购物车
数量:
1 mg
价格（CNY)
2,392.00
1 mg
添加至购物车
毒胡萝卜素是从伞形科植物Thapsia garganica分离得到的一种天然倍半萜内酯。这种肿瘤启动子会通过特异性抑制内质网 Ca2+-ATP 酶释放细胞内储存的 Ca2+；它不会直接影响细胞膜 Ca2+ATP 酶、Ins 1,4,5-P3 产量或蛋白激酶 C 活性。毒胡萝卜素还具有 1mg 包装 (T7458)。
仅供科研使用。不可用于诊断程序。
规格
标签类型未标记
分子式C34H50O12
数量1 mg
建议的储存条件在冷冻冰箱中（-5°C 至 -30°C）储存
运输条件室温
物理形态实心
产品类型毒胡萝卜素
Unit Size1 mg

引用和文献 (508)

引用和文献
Abstract
Calcium signaling.
Authors:Clapham DE
Journal:Cell
PubMed ID:7834745
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Authors:Thastrup O, Cullen PJ, Drøbak BK, Hanley MR, Dawson AP
Journal:Proc Natl Acad Sci U S A
PubMed ID:2138778
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces a rapid, dose-dependent release of stored Ca2+. The thapsigargin-releasable pool of microsomal Ca2+ includes the pools ... More
Muscarinic receptors modulate intracellular Ca(2+) concentration in hyaline cells of the chicken basilar papilla.
Authors:Lippe WR, Zirpel L, Stone JS
Journal:J Comp Physiol A Neuroethol Sens Neural Behav Physiol
PubMed ID:12073083
Nonsensory hyaline cells border the sensory epithelium of the auditory end-organ (basilar papilla) in birds and reptiles. Their innervation by cochlear cholinergic efferent fibers and the presence of contractile proteins suggest that hyaline cells may actively regulate basilar membrane mechanics. The cholinergic pharmacology of hyaline cells was studied by measuring ... More
Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.
Authors:Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S
Journal:J Cell Biol
PubMed ID:12082077
'The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered by ER stress had ... More
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.
Authors:Kokame K, Kato H, Miyata T
Journal:J Biol Chem
PubMed ID:11112790
'Herp is a 54-kDa membrane protein in the endoplasmic reticulum (ER). The mRNA expression level of Herp is increased by the accumulation of unfolded proteins in the ER. Transcriptional changes designed to deal with this type of ER stress is called the unfolded protein response (UPR). Most mammalian UPR-target genes ... More
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