Thymidine phosphorylase is angiogenic and promotes tumor growth.
Authors:Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R
Journal:Proc Natl Acad Sci U S A
PubMed ID:7532308
'Platelet-derived endothelial cell growth factor was previously identified as the sole angiogenic activity present in platelets; it is now known to be thymidine phosphorylase (TP). The effect of TP on [methyl-3H]thymidine uptake does not arise from de novo DNA synthesis and the molecule is not a growth factor. Despite this, ... More
Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo.
Authors:Gou D, Narasaraju T, Chintagari NR, Jin N, Wang P, Liu L,
Journal:Nucleic Acids Res
PubMed ID:15452203
RNA interference (RNAi) is a sequence-specific post-transcriptional gene silencing process. Although it is widely used in the loss-of-function studies, none of the current RNAi technologies can achieve cell-specific gene silencing. The lack of cell specificity limits its usage in vivo. Here, we report a cell-specific RNAi system using an alveolar ... More