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Invitrogen
Fyn Monoclonal Antibody (FYN-01)
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图: 1 / 11
Fyn Antibody (MA1-19331) in ICC/IF
Immunocytochemistry analysis of Fyn in human primary fibroblasts using anti-Fyn (FYN-01; green) Monoclonal antibody (Product # MA1-19331) using a dilution of 5 µg/mL. Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-19331
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Hamster,
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
FYN-01
抗原
Recombinant fragment of human Fyn (aa 7-176)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes Fyn, a 59 kDa non-receptor Src-family protein tyrosine kinase (intracellular antigen).
Immunoprecipitation: Preparation of cell lysate: 30 min on ice (orbital incubator) in lysing buffer, lysing buffer with N-dodecyl beta-D-maltoside (20 mM Tris/Cl, 100 mM NaCl pH 8,2, 1% laurylmaltosid (w/v), 50 mM NaF). The antibody FYN-01 apparently gives very specific signal (by 59 kDa), and nicely immunoprecipitants Fyn from cell lysates.
靶标信息
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C syn protooncogene; EC 2.7.10.2; kinase Fyn; MGC45350; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; Tyrosine-protein kinase Fyn
基因别名: AI448320; AW552119; FYN
UniProt ID: (Mouse) P39688
Entrez Gene ID: (Mouse) 14360
nucleotide binding
G-protein coupled receptor binding
glycoprotein binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
tubulin binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein complex binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
peptide hormone receptor binding
growth factor receptor binding
neuron migration
immune system process
protein phosphorylation
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
peptidyl-tyrosine phosphorylation
cell differentiation
forebrain development
negative regulation of protein ubiquitination
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of protein catabolic process
myelination
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
innate immune response
response to ethanol
protein autophosphorylation
dendrite morphogenesis
activated T cell proliferation
T cell receptor signaling pathway
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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