Invitrogen

Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody

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13 篇参考文献
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Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody

产品信息

PA5-17387

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看10篇已发表文章 10篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看2篇已发表文章 2篇已发表文章

免疫沉淀 (IP)

1:50
-

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Mouse

已发表种属

C. elegans, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr458 of mouse p85
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

190 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10985894

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Phosphoinositide 3-kinase (PI3K, phospho PI3K) Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: OTTHUMP00000009783; OTTHUMP00000009784; p55PIK; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit beta; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3-kinase subunit p85-beta; PI3K regulatory subunit alpha; PI3K regulatory subunit beta; PI3K regulatory subunit gamma; polypeptide 3; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-beta; RP4-533D7.2

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基因别名: AA414954; p50alpha; p55alpha; p55pik; p85alpha; p85beta; PI3K; Pik3r1; Pik3r2; Pik3r3

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UniProt ID: (Mouse) P26450, (Mouse) O08908, (Mouse) Q64143

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Entrez Gene ID: (Mouse) 18708, (Mouse) 18709, (Mouse) 18710

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功能
receptor binding insulin receptor binding insulin-like growth factor receptor binding platelet-derived growth factor receptor binding neurotrophin TRKA receptor binding protein binding calmodulin binding protein C-terminus binding transcription factor binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding estrogen receptor binding receptor tyrosine kinase binding ubiquitin protein ligase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity ATPase binding phosphoprotein binding kinase modulator
参与通路
cellular glucose homeostasis positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion glucose metabolic process protein phosphorylation transport negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of heart rate positive regulation of gene expression negative regulation of muscle cell apoptotic process phosphatidylinositol 3-kinase signaling protein transport negative regulation of cell-cell adhesion B cell differentiation positive regulation of cell migration positive regulation of tumor necrosis factor production response to insulin cellular response to insulin stimulus positive regulation of RNA splicing cellular response to UV response to endoplasmic reticulum stress phosphatidylinositol-3-phosphate biosynthetic process positive regulation of transcription factor import into nucleus negative regulation of apoptotic process regulation of phosphatidylinositol 3-kinase activity positive regulation of myoblast differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway negative regulation of smooth muscle cell proliferation protein stabilization response to glucocorticoid regulation of stress fiber assembly NFAT protein import into nucleus response to cAMP growth hormone receptor signaling pathway regulation of establishment of protein localization to plasma membrane positive regulation of endoplasmic reticulum unfolded protein response regulation of autophagy regulation of actin filament polymerization regulation of phosphorylation positive regulation of cell adhesion
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