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Invitrogen
Nitrotyrosine Polyclonal Antibody
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Nitrotyrosine Antibody (A-21285) in ICC/IF
Nitrated tyrosine residues in bovine pulmonary artery endothelial cells detected with rabbit anti-nitrotyrosine antibody. Fixed and permeabilized bovine pulmonary artery endothelial cells were treated with either degraded peroxynitrite (top panel) or 100 µM peroxynitrite (bottom panel) for five minutes at room temperature to induce protein nitration. Nitrated tyrosine residues were detected with our rabbit ... View More
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.jpg?time=20240507?time=20240507 "Nitrotyrosine Antibody (A-21285) in ICC/IF")
.jpg?time=20240507?time=20240507 "Nitrotyrosine Antibody (A-21285) in IHC (P)")
产品信息
A-21285
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
已发表种属
Chemical,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Keyhole limpet hemocyanin (KLH) containing nitrated tyrosines
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS, pH 7.2
内含物
5mM sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
