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Invitrogen
Lamin C Polyclonal Antibody
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产品信息
PA1-5827
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide made from the last 8 amino acids of lamin C, including an N-terminal lysine as a linker (KHHVSGSRR), coupled to KLH
偶联物
形式
Liquid
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Wet ice
RRID
产品详细信息
PA1-5827 detects Lamin C in human, rat and mouse samples.
PA1-5827 has been successfully used in immunofluorescence, Western blot and immunohistochemistry procedures. PA1-5827 reacts strongly in immunoblotting with fragments corresponding to peptide 319-572aa of Lamin C. When tested against nuclear protein extracts from HeLa cells it reacts with a single band migrating at 65 kDa.
The PA1-5827 immunogen is a synthetic peptide corresponding to the N-terminal residues K-HHVSGSRR of human lamin C, coupled to KLH.
靶标信息
Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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