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          System Message

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          LOADING ...
          See other LEF1 SIRNA Assays ›
          Gene Symbol:
          LEF1
          Gene Name:
          lymphoid enhancer binding factor 1
          Gene Aliases:
          LEF-1, TCF10, TCF1ALPHA, TCF7L3
          Chromosome Location:
          Chr.4: 108047545 - 108168956 on Build GRCh38
          UniGene ID:
          Hs.743478
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID 108839

          Purification
          Size
          Availability Inventoried
          Catalog # AM16708
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: LEF1
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_016269.4 NP_057353.1 6, 7 1919
          XM_005263046.3 XP_005263103.1 6, 7 923
          XM_005263047.1 XP_005263104.1 6, 7 547
          XM_006714233.1 XP_006714296.1 6, 7 624
          GenBank mRNA AF198532.1 - 6, 7 730
          AF288571.1 - 6, 7 1384
          AF294627.1 - 6, 7 730
          BC050632.2 - 6, 7 821 6054813

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Mouse: NM_001276403, NM_010703, X58636, AK158769, BC038305, and others.

          Panther Classification:

          Molecular Function -

          DNA-binding transcription factor

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          patterning of blood vessels
          osteoblast differentiation
          neural crest cell migration
          somitogenesis
          kidney development
          epithelial to mesenchymal transition
          sprouting angiogenesis
          transcription from RNA polymerase II promoter
          Wnt signaling pathway, calcium modulating pathway
          positive regulation of cell proliferation
          response to lithium ion
          positive regulation of gene expression
          positive regulation of epithelial to mesenchymal transition
          Wnt signaling pathway
          regulation of striated muscle tissue development
          dentate gyrus development
          hypothalamus development
          forebrain radial glial cell differentiation
          forebrain neuroblast division
          forebrain neuron differentiation
          formation of radial glial scaffolds
          regulation of cell-cell adhesion
          neutrophil differentiation
          positive regulation of cell growth
          embryonic limb morphogenesis
          positive regulation of cell migration
          BMP signaling pathway
          positive regulation of granulocyte differentiation
          mammary gland development
          organ regeneration
          negative regulation of interleukin-13 production
          negative regulation of interleukin-4 production
          negative regulation of interleukin-5 production
          T cell receptor V(D)J recombination
          B cell proliferation
          odontogenesis of dentin-containing tooth
          negative regulation of apoptotic process
          negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
          negative regulation of DNA binding
          steroid hormone mediated signaling pathway
          tongue development
          skin development
          positive regulation by host of viral transcription
          histone H3 acetylation
          histone H4 acetylation
          T-helper 1 cell differentiation
          negative regulation of striated muscle tissue development
          negative regulation of transcription, DNA-templated
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          alpha-beta T cell differentiation
          eye pigmentation
          paraxial mesoderm formation
          muscle fiber development
          sensory perception of taste
          palate development
          anatomical structure regression
          canonical Wnt signaling pathway
          face morphogenesis
          cell chemotaxis
          apoptotic process involved in morphogenesis
          chorio-allantoic fusion
          trachea gland development
          cellular response to cytokine stimulus
          cellular response to interleukin-4
          positive regulation of cell proliferation in bone marrow
          negative regulation of apoptotic process in bone marrow
          odontoblast differentiation
          negative regulation of estrogen receptor binding
          negative regulation of canonical Wnt signaling pathway
          apoptotic process involved in patterning of blood vessels
          beta-catenin-TCF complex assembly
          RNA polymerase II regulatory region sequence-specific DNA binding
          RNA polymerase II core promoter proximal region sequence-specific DNA binding
          transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
          transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
          DNA binding
          chromatin binding
          transcription factor activity, sequence-specific DNA binding
          transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
          protein binding
          beta-catenin binding
          transcription factor binding
          DNA binding, bending
          estrogen receptor activity
          estrogen receptor binding
          enhancer binding
          histone binding
          histone deacetylase binding
          cysteine-type endopeptidase inhibitor activity involved in apoptotic process
          sequence-specific DNA binding
          transcription regulatory region DNA binding
          gamma-catenin binding
          armadillo repeat domain binding
          C2H2 zinc finger domain binding

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