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          System Message

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          LOADING ...
          See other PARK2 SIRNA Assays ›
          Gene Symbol:
          Park2
          Gene Name:
          parkin RBR E3 ubiquitin protein ligase
          Gene Aliases:
          Park, Prkn
          Chromosome Location:
          Chr.1: 48880015 - 50069998 on Build Rnor_6.0
          UniGene ID:
          Rn.207194
          Species:
          Rat
          Species Specific ID (Flybase ID):
          -
          siRNA ID s132781

          Purification
          Size
          Availability Made To Order
          Catalog # 4390771
          Price 5,354.00
          Your Price
          Online offer:
          5354.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: Park2
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_020093.1 NP_064478.1 2 159
          GenBank mRNA AB039878.1 - 2 159
          AF168004.1 - 2 179
          AF210434.1 - 2 151
          AF257234.1 - 1 89
          AF343574.1 - 1 89
          AF381277.1 - 1 89
          AF381278.1 - 1 89
          AF381279.1 - 1 89
          AF381280.1 - 1 89
          AF381281.1 - 1 89
          GU322017.1 - 2 102
          GU322019.1 - 2 102
          GU322363.1 - 2 102
          GU322364.1 - 2 102
          GU345835.1 - 2 102
          GU345836.1 - 2 102
          KC774176.1 - 1 109

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Mouse: NM_016694, GU272056, AF250294, FJ555557, AF250293, and others.

          Panther Classification:

          Molecular Function -

          ubiquitin-protein ligase

          Gene Ontology Categories:

          Function(s) Process(es)

          protein polyubiquitination
          mitochondrial fission
          mitophagy
          negative regulation of protein phosphorylation
          synaptic transmission, dopaminergic
          startle response
          transcription, DNA-templated
          cellular protein modification process
          ubiquitin-dependent protein catabolic process
          protein monoubiquitination
          response to oxidative stress
          response to unfolded protein
          mitochondrion organization
          learning
          locomotory behavior
          adult locomotory behavior
          regulation of autophagy
          positive regulation of mitochondrial fusion
          negative regulation of mitochondrial fusion
          regulation of mitochondrion organization
          protein ubiquitination
          protein metabolic process
          regulation of protein ubiquitination
          negative regulation of actin filament bundle assembly
          positive regulation of proteasomal ubiquitin-dependent protein catabolic process
          negative regulation of glucokinase activity
          response to endoplasmic reticulum stress
          synaptic transmission, glutamatergic
          norepinephrine metabolic process
          dopamine metabolic process
          response to drug
          neuron maturation
          protein ubiquitination involved in ubiquitin-dependent protein catabolic process
          positive regulation of I-kappaB kinase/NF-kappaB signaling
          proteasome-mediated ubiquitin-dependent protein catabolic process
          positive regulation of DNA binding
          negative regulation of neuron apoptotic process
          cellular protein catabolic process
          negative regulation by host of viral genome replication
          positive regulation of transcription from RNA polymerase II promoter
          negative regulation of JNK cascade
          negative regulation of insulin secretion
          regulation of neurotransmitter secretion
          modulation of synaptic transmission
          protein stabilization
          regulation of protein transport
          response to corticosterone
          dopamine uptake involved in synaptic transmission
          mitochondrion localization
          protein autoubiquitination
          zinc ion homeostasis
          negative regulation of cell death
          neuron cellular homeostasis
          protein K63-linked ubiquitination
          protein localization to mitochondrion
          aggresome assembly
          protein K48-linked ubiquitination
          positive regulation of mitochondrial fission
          negative regulation of release of cytochrome c from mitochondria
          cellular response to toxic substance
          regulation of cellular response to oxidative stress
          negative regulation of neuron death
          positive regulation of proteasomal protein catabolic process
          negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
          positive regulation of protein linear polyubiquitination
          negative regulation of oxidative stress-induced neuron death
          positive regulation of tumor necrosis factor-mediated signaling pathway
          negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
          positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
          negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
          regulation of reactive oxygen species metabolic process
          negative regulation of reactive oxygen species metabolic process
          transcription regulatory region sequence-specific DNA binding
          G-protein coupled receptor binding
          actin binding
          ubiquitin-protein transferase activity
          protein binding
          zinc ion binding
          tubulin binding
          ligase activity
          kinase binding
          protein kinase binding
          PDZ domain binding
          Hsp70 protein binding
          heat shock protein binding
          ubiquitin conjugating enzyme binding
          ubiquitin protein ligase binding
          protein complex binding
          identical protein binding
          histone deacetylase binding
          ubiquitin binding
          chaperone binding
          ubiquitin protein ligase activity
          cullin family protein binding
          ubiquitin-specific protease binding
          F-box domain binding

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