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          System Message

          OKCancel
          LOADING ...
          See other GSK3B SIRNA Assays ›
          Gene Symbol:
          GSK3B
          Gene Name:
          glycogen synthase kinase 3 beta
          Gene Aliases:
          -
          Chromosome Location:
          Chr.3: 119821321 - 120094417 on Build GRCh38
          UniGene ID:
          Hs.445733
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID s6239
          Validated

          Purification
          Size
          Availability Inventoried
          Catalog # 4390824
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information
          • Citations (1)

          Genomic Map

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          siRNA Details

          Gene Symbol: GSK3B
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_001146156.1 NP_001139628.1 9, 10 2082
          NM_002093.3 NP_002084.2 10, 11 2121
          GenBank mRNA AB451356.1 - 9, 10 1099
          AK290897.1 - 9, 10 1455
          BC000251.1 - 10, 11 1370 3357620
          BC012760.2 - 9, 10 2081 3637163
          CR536510.1 - 9, 10 1099
          EU302497.1 - 9, 10 1099
          L33801.1 - 9, 10 1138

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Rat: NM_032080, XM_006248375, XM_008768745, XM_006248373, XM_006248374, and others.
          This siRNA also targets the following transcripts in Mouse: NM_019827, AK170965, BC006936, BC060743, AK154293, and others.

          Matching Taqman Gene Expression Assay:


          Hs00275656_m1

          Panther Classification:

          Molecular Function -

          non-receptor serine/threonine protein kinase

          Gene Ontology Categories:

          Function(s) Process(es)

          re-entry into mitotic cell cycle
          epithelial to mesenchymal transition
          positive regulation of cell-matrix adhesion
          glycogen metabolic process
          regulation of gene expression by genetic imprinting
          protein phosphorylation
          protein export from nucleus
          ER overload response
          dopamine receptor signaling pathway
          axonogenesis
          myoblast fusion
          aging
          circadian rhythm
          organ morphogenesis
          negative regulation of cardiac muscle hypertrophy
          positive regulation of peptidyl-threonine phosphorylation
          positive regulation of mitochondrial membrane potential
          negative regulation of neuron maturation
          response to activity
          Wnt signaling pathway
          cell migration
          peptidyl-serine phosphorylation
          peptidyl-threonine phosphorylation
          hippocampus development
          establishment of cell polarity
          negative regulation of protein complex assembly
          positive regulation of protein complex assembly
          negative regulation of protein binding
          positive regulation of protein binding
          response to estradiol
          positive regulation of proteasomal ubiquitin-dependent protein catabolic process
          response to insulin
          regulation of microtubule-based process
          positive regulation of peptidyl-serine phosphorylation
          negative regulation of smooth muscle cell apoptotic process
          protein localization to microtubule
          intracellular signal transduction
          cellular response to hepatocyte growth factor stimulus
          cellular response to interleukin-3
          cellular response to erythropoietin
          response to drug
          negative regulation of apoptotic process
          proteasome-mediated ubiquitin-dependent protein catabolic process
          negative regulation of MAP kinase activity
          positive regulation of neuron apoptotic process
          positive regulation of GTPase activity
          hypermethylation of CpG island
          canonical Wnt signaling pathway involved in positive regulation of apoptotic process
          fat cell differentiation
          negative regulation of glycogen biosynthetic process
          positive regulation of protein catabolic process
          positive regulation of axon extension
          positive regulation of transcription from RNA polymerase II promoter
          protein autophosphorylation
          positive regulation of protein export from nucleus
          regulation of neuronal synaptic plasticity
          positive regulation of smooth muscle cell proliferation
          negative regulation of dendrite morphogenesis
          negative regulation of nitric-oxide synthase activity
          negative regulation of NFAT protein import into nucleus
          canonical Wnt signaling pathway
          intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          cellular response to hydrogen peroxide
          superior temporal gyrus development
          cellular response to mechanical stimulus
          cellular response to iron(II) ion
          cellular response to lithium ion
          response to epinephrine
          negative regulation of canonical Wnt signaling pathway
          extrinsic apoptotic signaling pathway in absence of ligand
          chemical synaptic transmission, postsynaptic
          regulation of cellular response to heat
          negative regulation of protein localization to nucleus
          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
          positive regulation of neuron death
          response to L-glutamate
          cellular response to dopamine
          negative regulation of dopaminergic neuron differentiation
          beta-catenin destruction complex assembly
          beta-catenin destruction complex disassembly
          response to insulin-like growth factor stimulus
          response to ultrasound
          response to angiotensin
          negative regulation of type B pancreatic cell development
          positive regulation of excitatory postsynaptic potential
          negative regulation of glycogen (starch) synthase activity
          positive regulation of DNA biosynthetic process
          positive regulation of stem cell differentiation
          negative regulation of neuron migration
          RNA polymerase II transcription factor binding
          p53 binding
          protein kinase activity
          protein serine/threonine kinase activity
          integrin binding
          protein binding
          ATP binding
          beta-catenin binding
          kinase activity
          protein kinase binding
          ubiquitin protein ligase binding
          protein kinase A catalytic subunit binding
          ionotropic glutamate receptor binding
          tau protein binding
          tau-protein kinase activity
          NF-kappaB binding

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          Citations (1)

          Glycogen synthase kinase-3beta: a prognostic marker and a potential therapeutic target in human bladder cancer.
          Authors
          Naito S, Bilim V, Yuuki K, Ugolkov A, Motoyama T, Nagaoka A, Kato T, Tomita Y
          Journal
          Clin Cancer Res - Page No 5124 (Mon Nov 01 00:00:00 UTC 2010)
          Volume (Year)
          16 (2010)
          Product Usage
          -

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