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产品信息
PHC1506
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
分子量
46.2 kDa
分类
Recombinant
类型
Protein
纯度
>95% by SDS-PAGE
内毒素浓度
<0.1 ng/µg
活性
ED50 < 3 ng/mL; determined by the dose-depdent inhibition of alkaline phosphatase production induced by BMP-4 (5 ng/mL) in ATDC-5 chondrogenic cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Carrier-Free
Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in 10 mM acetic acid to a concentration of 0.1-1.0 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in appropriate buffered solution containing a carrier protein, such as 0.1% HSA or BSA.
Storage: The lyophilized protein is stable at room temperature for 3 weeks. Store at -20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at 4°C for 2-7 days, or at -20°C. Avoid repeated freeze-thaw cycles.
靶标信息
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Noggin; Noggin precursor; symphalangism 1 (proximal)
基因别名: NOG; SYM1; SYNS1; SYNS1A
UniProt ID: (Human) Q13253
Entrez Gene ID: (Human) 9241
