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Invitrogen
Human PCSK9 (NARC1) His-tag Recombinant Protein
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产品信息
RP-88142
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
HEK293 cells
氨基酸序列
Human PCSK9, amino acids Met1-Gln692 (Accession # NP_777596.2) with a C-terminal His-tag
标签
His-tag
分子量
72.5 kDa
分类
Recombinant
类型
Protein
纯度
>95% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
活性
Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag on ProA Biosensor, can bind Recombinant Human PCSK9 Protein, His Tag with an affinity constant of 16nM as determined in BLI assay. Immobilized Anti-PCSK9(Amg)-IgG2 Antibody at 2 µg/mL (100 µL/well) can bind Recombinant Human PCSK9 / NARC1 Protein (His Tag), the EC50 is 14-52 ng/mL.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (500 µL) be added to the vial to prepare a stock solution of 1.11 mg/mL.
Concentration is measured by UV.
靶标信息
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9
基因别名: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052
UniProt ID: (Human) Q8NBP7
Entrez Gene ID: (Human) 255738
