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Invitrogen
Human R-Spondin 1 (aa 1-146) His-tag Recombinant Protein
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产品信息
RP-88158
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
HEK293 cells
氨基酸序列
Met1-Ala146
标签
His-tag
分子量
23 kDa
分类
Recombinant
类型
Protein
纯度
>98% as determined by SDS-PAGE.
活性
1. Measured by its ability to bind recombinant mouse CD36 in a functional ELISA. 2. Measured by its ability to induce activation of beta-catenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. The ED50 for this effect is typically 0.1-0.5 µg/mL in the presence of 5 ng/mL recombinant mouse Wnt3a.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (4000 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
靶标信息
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40906; hRspo1; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1
基因别名: CRISTIN3; RSPO; RSPO1
UniProt ID: (Human) Q2MKA7
Entrez Gene ID: (Human) 284654
