Invitrogen

Human SYPL2 Synthetic Peptide

Name: Human SYPL2 Synthetic Peptide
Brand: Invitrogen
SKU: PEP-0890

说明书

技术支持

说明书

技术支持

说明书

技术支持

产品信息

PEP-0890

应用

建议稀释比

已发表文章

中和实验 (Neu)

Assay-dependent

产品规格

种属反应

Human

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with 0.1% BSA

内含物

0.02% sodium azide

保存条件

-20°C

产品详细信息

This peptide corresponds to 15 amino acids near the carboxy terminus of human SYPL2.

PEP-0890 can be used as a blocking peptide with polyclonal antibody PA5-20776.

靶标信息

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.

仅用于科研。不用于诊断过程。未经明确授权不得转售。