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Invitrogen
Human VEGFR3 (Flt-4) Fc Chimera Recombinant Protein
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产品信息
RP-88180
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
HEK293 cells
氨基酸序列
Human VEGFR3, amino acids Met1-Ile776 (Accession # NP_002011.2) with a C-terminal human IgG1 Fc region
标签
Fc-tag
分子量
111.3 kDa
分类
Recombinant
类型
Protein
纯度
>97% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
活性
Measured by its binding ability in a functional ELISA. 1. Immobilized recombinant human VEGFR3 at 5 µg/ml (100 µL/well) can bind recombinant human VEGF-D at a linear range of 62.5-2000 ng/mL. 2. Immobilized recombinant human VEGF-C at 10 µg/ml (100 µL/well) can bind recombinant human VEGFR3 at a linear range of 0.64-80 ng/mL. 3. Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (900 µL) be added to the vial to prepare a stock solution of 1.11 mg/mL.
Concentration is measured by UV.
靶标信息
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLT-4; Fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; soluble VEGFR 3; sVEGFR 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGF R3; VEGFR-3
基因别名: FLT-4; FLT4; FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3
UniProt ID: (Human) P35916
Entrez Gene ID: (Human) 2324
