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Gibco
Rat IL-10 Recombinant Protein
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产品信息
PRC0104
产品规格
种属
Rat
Expression System
E. coli
氨基酸序列
Rat IL-10 recombinant protein contains 160 amino acids
分子量
18.7 kDa
分类
Recombinant
类型
Protein
纯度
>98% by SDS-PAGE and HPLC
内毒素浓度
<0.1 ng/µg
活性
ED50 ≤ 10 ng/mL; determined by the dose-dependent inhibition of antigen-specific T-cells.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
5mM tris, pH 7.2
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Reconstitution: We recommend that the vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized rat IL-10 in 5 mM Tris, pH 7.2, to a concentration of 0.1-1.0 mg/mL. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA.
Storage: This lyophilized preparation is stable at 2°C to 8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2°C to 8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C. Avoid repeated freeze/thaw cycles.
靶标信息
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CSIF; Cytokine synthesis inhibitory factor; H-IL-10; il 10; IL-10; ILN; Interleukin; Interleukin-10; Interleukin10; MGC126450; MGC126451; RP11-262N9.1
基因别名: Il-10; Il10; IL10X
UniProt ID: (Rat) P29456
Entrez Gene ID: (Rat) 25325
