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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
AI627006; APG4 (ATG4) autophagy-related homolog A; APG4 autophagy 4 homolog A; APG4A; ATG4 autophagy related 4 homolog A; Atg4a; Atg4al; Atg4al1; AUTL2; AUT-like 2 cysteine endopeptidase; AUT-like 2, cysteine endopeptidase; autophagin 2; autophagin-2; autophagy 4 homolog A; autophagy related 4 homolog A; autophagy related 4A cysteine peptidase; autophagy related 4A, cysteine peptidase; autophagy related 4A, cysteine peptidase-like 1; autophagy-related 4A; autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; AV169859; cysteine protease APG4A; cysteine protease ATG4A; hAPG4A; MGC107179
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