ATP6V0A1 Antibodies

Target Information

ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles.

Synonyms

a1; AA959968; adenosine triphosphatase; ATP6a1; ATP6N1; ATP6N1A; Atp6v0a1; ATPase H+ transporting lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase H+ transporting V0 subunit a1; ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1A (110/160 kDa); ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a; ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal V0 subunit a1; Atpv0a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; Stv1; V-A; vacuolar adenosine triphosphatase subunit Ac116; vacuolar H+-ATPase subunit; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; vacuolar proton-translocating ATPase a1 isoform; vacuolar-type H(+)-ATPase 115 kDa subunit; V-ATPase 116 kDa; V-ATPase 116 kDa isoform a1; V-ATPase 116 kDa subunit; V-ATPase 116 kDa subunit a1; V-ATPase a1; v-H+ATPase subunit a1; Vph1; Vpp1; Vpp-1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 1; V-type proton ATPase 116 kDa subunit a isoform 1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a1