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CHMP2B, also known as CHMP2.5 or vacuolar protein-sorting-associated protein 2-2, is a 213 amino acid cytosolic protein. Widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes, CHMP2B associates directly with CHMP2A and vps4 for the disassembly of the ESCRT-III complex. Defects in the gene encoding CHMP2B have been shown to cause chromosome 3-linked frontotemporal dementia (FTD3).
1190006E07Rik; ALS17; CGI-84; Charged multivesicular body protein 2b; charged multivesicular body protein 2Bb; CHMP family; CHMP2.5; CHMP2B; chmp2bb; chmp2bl; chromatin modifying protein 2B; chromatin modifying protein 2B, like; chromatin modifying protein 2Bb; chromatin-modifying protein 2b; DMT1; hVps2-2; hypothetical protein LOC615954; hypothetical protein zgc:77025; RGD1306781; si:ch211-106g5.3; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; VPS2-2; VPS2B; zgc:77025
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