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DENND5A (DENN domain-containing protein 5A) is a guanine nucleotide exchange factor (GEF) which activates RAB6A and RAB39A/RAB39B. It promotes the exchange of GDP to GTP by converting inactive GDP-bound Rab proteins to their active GTP form. DENND5A is also involved in the negative regulation of neurtie outgrowth. Mutations affecting this gene can result in epileptic encephalopathy, early infantile, 49 (EIEE49).
1500012B19Rik; AJ245569; AW496491; DENN domain containing 5A; DENN domain-containing protein 5A; DENN/MADD domain containing 5A; DENND5A; KIAA1091; mKIAA1091; ORF37; Rab6 interacting protein 1; rab6-interacting protein 1; RAB6IP1
100 µL
50 µg
100 µL