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DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
D030002L11Rik; DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ heat shock protein family (Hsp40) member C13; dnaJ homolog subfamily C member 13; DNAJC13; Gm1124; j-domain containing protein, required for endocytosis; KIAA0678; mKIAA0678; PARK21; receptor mediated endocytosis RME-8; required for receptor-mediated endocytosis 8; Rme8; RME-8
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