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Immunogen sequence: VTPGGFDQIN PATNRVLCSY DYRNIEGFVD LSDYQGGFCI LYGGFSRLHL FASEQREEII KSAIDHAGNY IGISLRIRKE PLEFEQYLNL RF
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 92%.
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; Required for receptor-mediated endocytosis 8; RME-8
基因别名: DNAJC13; KIAA0678; PARK21; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317