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Choline-specific glycerophosphodiester phosphodiesterase. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently.
4833421B01Rik; B830047L21Rik; choline-specific glycerophosphodiester phosphodiesterase; D8Ertd514e; ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; E-NPP 6; Enpp6; E-NPP6; Glycerophosphocholine cholinephosphodiesterase; GPC-Cpde; Npp6; NPP-6; UNQ1889/PRO4334
400 µL
100 µL
100 µL
50 µg
100 µL
100 µL