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F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
2700071L08Rik; EMBL:AAI66990.1}; F-box and WD repeat domain containing 2; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; F-box and WD-40 domain-containing protein 2 {ECO:0000312; F-box protein Fbw2; F-box/WD repeat-containing protein 2; FBW2; FBXW2; fbxw2 {ECO:0000312; FWD2; MD6; MGC117371; Protein MD6; RGD:1310460}
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