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This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
4930406E12Rik; ADP-ribosylation factor binding protein 1; ADP-ribosylation factor-binding protein GGA1; AU016030; AW209092; gamma-adaptin related protein 1; gamma-adaptin-related protein 1; GGA1; golgi associated, gamma adaptin ear containing, ARF binding protein 1; golgi-associated, gamma adaptin ear containing, ARF binding protein 1; golgi-localized, gamma ear-containing, ARF-binding protein 1
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