KDM1B Antibodies

Target Information

The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.

Synonyms

4632428N09Rik; AI482520; amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Aof1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; KDM1B; LSD2; lysine (K)-specific demethylase 1B; lysine demethylase 1B; lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2