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Invitrogen
KDM1B Recombinant Rabbit Monoclonal Antibody (15F3)
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KDM1B Antibody (MA5-49995) in WB
Western blot analysis of KDM1B in A549 whole cell lysate, HeLa whole cell lysate using a dilution of 1:2,000. Samples were incubated with KDM1B monoclonal antibody (Product # MA5-49995). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 93, 66, 20 kDa. Observed band size: 90-95, 17-28 kDa.
产品信息
MA5-49995
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15F3
抗原
A synthesized peptide derived from human KDM1B
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Flavin-containing amine oxidase domain-containing protein 1; lysine (K)-specific demethylase 1B; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
基因别名: AOF1; bA204B7.3; C6orf193; dJ298J15.2; KDM1B; LSD2
UniProt ID: (Human) Q8NB78
Entrez Gene ID: (Human) 221656
