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RRAGC (Ras-related GTP-binding protein C) is a monomeric guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulations of the mTORC1 signaling cascade. RRAGC forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. It cycles between an inactive GTP-bound and an active GDP-bound form. RRAGC, in its active form, participates in the re-localization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This re-localization is a crucial step in the activation of the TOR signaling cascade by amino acids.
AU041672; GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RAGC; Ras related GTP binding C; Ras-related GTP binding C; ras-related GTP-binding protein C; RRAGC; small GTPase homolog; small GTPase, homolog; TIB929; YGR163W
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