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SEC23IP is involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.
D7Ertd373e; MSTP053; P125; P125A; SEC23 interacting protein; SEC23-interacting protein; Sec23-interacting protein p125; SEC23-interacting protein-like protein; SEC23IP
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