SS18/SSX Antibodies

Antibodies that detect SS18/SSX can be used in several scientific applications, including Immunohistochemistry and Western Blot. These antibodies target SS18/SSX in Human samples. Our SS18/SSX recombinant monoclonal antibodies are developed in Rabbit. Find the SS18/SSX antibody... Antibodies that detect SS18/SSX can be used in several scientific applications, including Immunohistochemistry and Western Blot. These antibodies target SS18/SSX in Human samples. Our SS18/SSX recombinant monoclonal antibodies are developed in Rabbit. Find the SS18/SSX antibody that fits your needs. Choose from 1 of 2 SS18/SSX... Antibodies that detect SS18/SSX can be used in several scientific applications, including Immunohistochemistry and Western Blot. These antibodies target SS18/SSX in Human samples. Our SS18/SSX recombinant monoclonal antibodies are developed in Rabbit. Find the SS18/SSX antibody that fits your needs. Choose from 1 of 2 SS18/SSX antibodies.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop... Antibodies that detect SS18/SSX can be used in several scientific applications, including Immunohistochemistry and Western Blot. These antibodies target SS18/SSX in Human samples. Our SS18/SSX recombinant monoclonal antibodies are developed in Rabbit. Find the SS18/SSX antibody that fits your needs. Choose from 1 of 2 SS18/SSX antibodies.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

靶标信息

The SS18/SSX fusion gene is pivotal in the pathogenesis of synovial sarcoma, a rare type of cancer typically arising in the soft tissues around joints in adolescents and young adults. The SS18-SSX fusion results from an exchange between chromosome 18's SS18 gene and one of the SSX genes (often SSX1 or SSX2 on the X chromosome), creating a hybrid protein responsible for oncogenic transformation. This fusion protein interacts with the SWI/SNF (BAF) chromatin remodeling complex, disrupting normal gene regulation and leading to tumorigenesis. Clinically, the SS18/SSX fusion serves as a crucial molecular diagnostic marker, aiding in the identification of synovial sarcoma. Moreover, SS18-SSX fusion proteins lack DNA-binding motifs but still effectively alter gene expression through epigenetic mechanisms. Despite the establishment of this fusion gene as a diagnostic marker, its prognostic value concerning survival rates remains debated. Additionally, novel antibodies targeting the SS18-SSX fusion protein have shown high specificity and sensitivity, offering potential advancements for diagnostic procedures and therapeutic strategies. Understanding the molecular and clinicopathological profiles influenced by this fusion gene is essential for developing targeted treatments for synovial sarcoma.