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NeoBiotechnologies
SS18-SSX (Marker of Synovial Sarcoma) Recombinant Rabbit Monoclonal Antibody (SS18.SSX/12628R)
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产品信息
RBM1-12628-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SS18.SSX/12628R
抗原
Recombinant fragment corresponding to the fusion site of human SS18-SSX protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The SS18/SSX fusion gene is pivotal in the pathogenesis of synovial sarcoma, a rare type of cancer typically arising in the soft tissues around joints in adolescents and young adults. The SS18-SSX fusion results from an exchange between chromosome 18's SS18 gene and one of the SSX genes (often SSX1 or SSX2 on the X chromosome), creating a hybrid protein responsible for oncogenic transformation. This fusion protein interacts with the SWI/SNF (BAF) chromatin remodeling complex, disrupting normal gene regulation and leading to tumorigenesis. Clinically, the SS18/SSX fusion serves as a crucial molecular diagnostic marker, aiding in the identification of synovial sarcoma. Moreover, SS18-SSX fusion proteins lack DNA-binding motifs but still effectively alter gene expression through epigenetic mechanisms. Despite the establishment of this fusion gene as a diagnostic marker, its prognostic value concerning survival rates remains debated. Additionally, novel antibodies targeting the SS18-SSX fusion protein have shown high specificity and sensitivity, offering potential advancements for diagnostic procedures and therapeutic strategies. Understanding the molecular and clinicopathological profiles influenced by this fusion gene is essential for developing targeted treatments for synovial sarcoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein SSXT; Protein SYT; SS18-SSX; Synovial sarcoma translocated to X chromosome protein; synovial sarcoma translocation, chromosome 18; synovial sarcoma, translocated to X chromosome; SYT-SSX1
基因别名: SS18; SSXT; SYT
UniProt ID: (Human) Q15532
Entrez Gene ID: (Human) 6760
