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Pan-MAGUK Monoclonal Antibody (K28/86), FL490

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Pan-MAGUK Monoclonal Antibody (K28/86), FL490

Product Details

75-029-FL490

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Xenopus, Zebrafish

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K28/86

Immunogen

Fusion protein amino acids 77-299 of human PSD-95/SAP90 produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

FL490 FL490 FL490

Excitation/Emission Max

491/515 nm

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Pan-MAGUK refers to the collective group of Membrane-Associated Guanylate Kinase (MAGUK) family proteins, which are scaffolding proteins involved in organizing signaling complexes at cellular membranes. These proteins play critical roles in synaptic signaling, cell adhesion, and maintaining the structure of tight junctions. Dysregulation of MAGUK proteins has been linked to various neurological disorders and cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Channel-associated protein of synapse-110; Chapsyn-110; discs large homolog 2; discs large homolog 3; discs large homolog 4; discs, large homolog 4; Disks large homolog 1; Disks large homolog 2; Disks large homolog 3; Disks large homolog 4; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; membrane associated guanylate kinase; MAGUK; Neuroendocrine-DLG; Postsynaptic density protein 93; Postsynaptic density protein 95; Postsynaptic density protein PSD-93; PSD-93; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD-95/SAP90-related protein 1; SAP-102; SAP-90; SAP-97; SAP-97A; SAP102; SAP97A; Synapse-associated protein 102; Synapse-associated protein 90; Synapse-associated protein 97; Synapse-associated protein 97A; synapse-associated protein SAP90; synaptic density protein PSD-93; XLMR

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Gene Aliases: A330103J02Rik; B130052P05Rik; B230218P12Rik; B330007M19Rik; DLG1; DLG2; DLG3; DLG4; Dlgh1; Dlgh2; Dlgh3; Dlgh4; E-dlg/SAP97; fa66c08; fa66e02; fd02c12; fu95c12; Gm1197; im:7138640; KIAA1232; mKIAA1232; mKIAA4187; PSD-93; PSD-95; PSD93; PSD95; sap-90; SAP-97; SAP-97A; SAP102; SAP90; SAP90A; SAP97; si:ch211-276g21.1; wu:fa66c08; wu:fa66e02; wu:fc34d02; wu:fd02c12; wu:fu95c12; zgc:55810

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UniProt ID: (Rat) Q62696, (Mouse) Q811D0, (Mouse) Q91XM9, (Rat) Q63622, (Rat) Q62936, (Mouse) P70175, (Rat) P31016, (Mouse) Q62108, (Zebrafish) Q5PYH6, (Zebrafish) Q5PYH7

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Entrez Gene ID: (Rat) 25252, (Mouse) 13383, (Mouse) 23859, (Rat) 64053, (Rat) 58948, (Mouse) 53310, (Rat) 29495, (Mouse) 13385, (Zebrafish) 114446, (Zebrafish) 497638, (Zebrafish) 564081, (Western clawed frog) 779559, (Zebrafish) 100000823

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Function(s)
guanylate kinase activity protein binding protein C-terminus binding potassium channel regulator activity protein kinase binding phosphatase binding PDZ domain binding mitogen-activated protein kinase kinase binding protein complex scaffold ionotropic glutamate receptor binding ion channel binding L27 domain binding kinase binding protein phosphatase binding protein heterodimerization activity protein domain specific binding ubiquitin protein ligase binding receptor binding beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding protein complex binding acetylcholine receptor binding glutamate receptor binding scaffold protein binding structural molecule activity neurexin family protein binding neuroligin family protein binding scaffold/adaptor protein
Process(es)
ureteric bud development branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye T cell cytokine production actin filament organization cell adhesion chemical synaptic transmission nervous system development protein localization positive regulation of cell proliferation single organismal cell-cell adhesion peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization membrane raft organization regulation of myelination activation of protein kinase activity regulation of protein localization T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering positive regulation of potassium ion transport establishment or maintenance of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle nucleotide phosphorylation reproductive structure development embryonic skeletal system morphogenesis tissue morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation negative regulation of protein kinase B signaling hard palate development bicellular tight junction assembly protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane receptor localization to synapse positive regulation of multicellular organism growth positive regulation of developmental growth negative regulation of phosphatase activity sensory perception of pain neuronal ion channel clustering establishment of planar polarity negative regulation of receptor internalization protein complex assembly positive regulation of cytosolic calcium ion concentration synaptic vesicle maturation social behavior protein localization to synapse locomotory exploration behavior establishment of protein localization regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis vocalization behavior AMPA glutamate receptor clustering regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior signal transduction locomotory behavior response to cocaine regulation of neuronal synaptic plasticity embryo development cell-cell adhesion neurotransmitter receptor localization to postsynaptic specialization membrane
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