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Proteintech
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Immunogen sequence: EVYKLVIPIL EAHREFRKLT LTHSKLQRAF DSIVNKDHKR MFGTYFRVGF FGSKFGDLDE QEFVYKEPAI TKLPEISHRL EAFYGQCFGA EFVEVIKDST PVDKTKLDPN KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LRRFMYTTPF TLEGRPRGEL HEQYRRNTVL TTMHAFPYIK TRISVIQKEE FVLTPIEVAI EDMKKKTLQL AVAINQEPPD AKMLQMVLQG SVGATVNQGP LEVAQVFLAE IPADPKLYRH HNKLRLCFKE FIMRCGEAVE KNKRLITADQ REYQQELKKN YNKLKENLRP MIERKIPELY KPIFRVESQK RDSFHRSSFR KCETQLSQGS
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1200017A24Rik; Dedicator of cytokinesis protein 8; epididymis luminal protein 205
Gene Aliases: DOCK8; HEL-205; MRD2; ZIR8
UniProt ID: (Human) Q8NF50
Entrez Gene ID: (Human) 81704
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