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Invitrogen
ADAM17 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-31074
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence LQRQNRVDSKETEC, from the C Terminus.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX13535-PEP)..
Expected to cross-react with Chinese Hamster due to sequence homology.
Detects a band of approximately 125-130 kDa (predicted molecular weight: 95 or when glycosylated 130 kDa).
靶标信息
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a disintegrin and metalloproteinase; a disintegrin and metalloproteinase 17; ADAM; ADAM metallopeptidase domain 18; ADAMs; cartilage snake venom-like protease; CD156b antigen; metalloendopeptidases; snake venom-like protease; TNF-alpha convertase; TNF-alpha convertase enzyme; TNF-alpha converting enzyme; tumor necrosis factor, alpha, converting enzyme; tumor overexpression; unnamed protein product
基因别名: ADAM18; CD156B; CSVP; HYPT16; NISBD; NISBD1; TACE
UniProt ID: (Human) P78536
Entrez Gene ID: (Human) 6868
response to hypoxia
neutrophil mediated immunity
germinal center formation
production of molecular mediator involved in inflammatory response
positive regulation of leukocyte chemotaxis
proteolysis
membrane protein ectodomain proteolysis
cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of T cell chemotaxis
protein processing
signal release
B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
response to lipopolysaccharide
positive regulation of chemokine production
positive regulation of tumor necrosis factor production
regulation of mast cell apoptotic process
T cell differentiation in thymus
cell adhesion mediated by integrin
wound healing, spreading of epidermal cells
amyloid precursor protein catabolic process
protein kinase B signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of epidermal growth factor receptor signaling pathway
spleen development
cell motility
defense response to Gram-positive bacterium
cellular response to high density lipoprotein particle stimulus
commissural neuron axon guidance
negative regulation of cold-induced thermogenesis
cytokine precursor processing
signaling receptor ligand precursor processing
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of vascular endothelial cell proliferation
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