Search

  • 联系我们
  • 货号直购

Invitrogen

ADAM17 Monoclonal Antibody (C7)

查看其他18个ADAM17抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
ADAM17 Monoclonal Antibody (C7)

产品信息

MA565986

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

5-30 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

C7

抗原

Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) (Lys226-Arg473)
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3715134

靶标信息

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM; ADAM 17; ADAM metallopeptidase domain 18; ADAMs; cartilage snake venom-like protease; CD156b; CD156b antigen; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; Snake venom-like protease; TNF-alpha convertase; TNF-alpha convertase enzyme; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme; tumor overexpression; unnamed protein product

查看更多 收起

基因别名: ADAM17; ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE

查看更多 收起

UniProt ID: (Human) P78536, (Mouse) Q9Z0F8, (Rat) Q9Z1K9

查看更多 收起

Entrez Gene ID: (Human) 6868, (Mouse) 11491, (Rat) 57027

查看更多 收起

功能
endopeptidase activity metalloendopeptidase activity Notch binding interleukin-6 receptor binding integrin binding protein binding peptidase activity metallopeptidase activity hydrolase activity SH3 domain binding cytokine binding PDZ domain binding tumor necrosis factor binding metal ion binding metallodipeptidase activity metalloendopeptidase activity involved in amyloid precursor protein catabolic process zinc ion binding protease
参与通路
response to hypoxia neutrophil mediated immunity germinal center formation production of molecular mediator involved in inflammatory response positive regulation of leukocyte chemotaxis proteolysis membrane protein ectodomain proteolysis cell adhesion epidermal growth factor receptor signaling pathway Notch signaling pathway Notch receptor processing positive regulation of cell proliferation response to xenobiotic stimulus positive regulation of signal transduction positive regulation of T cell chemotaxis negative regulation of neuron projection development protein processing signal release B cell differentiation positive regulation of cell growth positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway response to lipopolysaccharide positive regulation of chemokine production positive regulation of tumor necrosis factor production regulation of mast cell apoptotic process T cell differentiation in thymus cell adhesion mediated by integrin wound healing, spreading of epidermal cells amyloid precursor protein catabolic process protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of epidermal growth factor receptor signaling pathway spleen development regulation of axon regeneration cell motility defense response to Gram-positive bacterium cellular response to high density lipoprotein particle stimulus commissural neuron axon guidance negative regulation of cold-induced thermogenesis cytokine precursor processing signaling receptor ligand precursor processing positive regulation of G1/S transition of mitotic cell cycle positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of vascular endothelial cell proliferation regulation of neuron migration positive regulation of protein phosphorylation positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway response to drug negative regulation of apoptotic process positive regulation of epidermal growth factor-activated receptor activity PMA-inducible membrane protein ectodomain proteolysis positive regulation of cellular component movement response to high density lipoprotein particle integrin-mediated signaling pathway negative regulation of interleukin-8 production
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持