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Fabgennix
CCDC98 Polyclonal Antibody
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产品信息
ABRX1-112AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 350-400 on rat BRCA1-A complex subunit Abraxas protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
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生物信息学
蛋白别名: BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A
基因别名: 3830405G04Rik; 5630400M01Rik; Abra1; ABRAXAS1; AI506069; AL024423; AV118690; Ccdc98; Fam175a; RGD1305287
UniProt ID: (Mouse) Q8BPZ8, (Rat) Q5I0F1
Entrez Gene ID: (Mouse) 70681, (Rat) 289468
