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Invitrogen
CaV3.1 Monoclonal Antibody (N178A/9), APC
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图: 1 / 3
CaV3.1 Antibody (MA5-45543) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Cav3.1 monoclonal antibody (Product # MA5-45543) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min at RT, 5 min at RT. Localization: Cell Membrane, Membrane, Cytoplasm, Nucleoplasm. Magnification: 60X. (A) DAPI (blue) nuclear st... View More
产品信息
MA5-45543
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N178A/9
抗原
Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
1 µg/mL of MA5-45543 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately <200kDa. Does not cross-react with Cav3.2.
This antibody was formerly sold as clone S178A-9.
靶标信息
Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha1G-ae; Alpha1G-aef; Alpha1G-af; Alpha1G-bc; Alpha1G-bcd; Alpha1G-bce; Alpha1G-bcef; Alpha1G-be; CACNA1G-a; T-type; CACNA1G-b; T-type; calcium channel, voltage-dependent, T type, alpha 1G subunit; CaV T1; Cav3 1; cav3 1c; Cav3.1c; low voltage-activated T-type calcium channel alpha-1 subunit Cav3.1; low-voltage-activated calcium channel; MGC117234; NBR13; unnamed protein product; voltage-dependent calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel alpha 1G subunit; Voltage-dependent T-type calcium channel subunit alpha-1G; voltage-gated calcium channel; Voltage-gated calcium channel subunit alpha Cav3.1
基因别名: [a]1G; a1G; alpha-1G; Ca(V)T.1; CACNA1G; Cav3.1; Cav3.1d; KIAA1123; mKIAA1123; NBR13; SCA42; SCA42ND
UniProt ID: (Human) O43497
Entrez Gene ID: (Human) 8913, (Rat) 29717, (Mouse) 12291
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
high voltage-gated calcium channel activity
low voltage-gated calcium channel activity
voltage-gated calcium channel activity involved in AV node cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
scaffold protein binding
protein binding
voltage-gated ion channel
action potential
regulation of heart rate
sinoatrial node development
ion transport
calcium ion transport
chemical synaptic transmission
response to nickel cation
ion transmembrane transport
regulation of membrane potential
transmembrane transport
regulation of atrial cardiac muscle cell membrane depolarization
regulation of biological quality
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
SA node cell action potential
AV node cell action potential
SA node cell to atrial cardiac muscle cell signalling
AV node cell to bundle of His cell signaling
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
positive regulation of cytosolic calcium ion concentration
artery smooth muscle contraction
regulation of ion transmembrane transport
positive regulation of calcium ion-dependent exocytosis
regulation of calcium ion transport
calcium ion transport into cytosol
cellular response to dexamethasone stimulus
membrane depolarization during action potential
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