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Invitrogen
DLC1 Polyclonal Antibody
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DLC1 Antibody (PA5-106902) in IHC (P)
Immunohistochemistry analysis of DLC1 in rat liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DLC1 polyclonal antibody (Product # PA5-106902) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106902
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DLC1(Accession Q96QB1), corresponding to amino acid residues N51-E101.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DLC1.
靶标信息
This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARHGAP 7; Deleted in liver cancer 1 protein; Deleted in liver cancer 1 protein homolog; DLC 1; DLC-1; epididymis secretory sperm binding protein; FLJ21120; HP protein; p122 RhoGAP; p122-RhoGAP; p122RhoGAP ortholog; rho GTPase activating protein 7; Rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StAR-related lipid; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; STARD 12; StARD12; START domain-containing protein 12; transfer protein 12; unnamed protein product
基因别名: A730069N07Rik; ARHGAP7; dlc-1; DLC1; HP; KIAA1723; p122-RhoGAP; RhoGAP; STARD12
UniProt ID: (Human) Q96QB1, (Mouse) Q9R0Z9
Entrez Gene ID: (Human) 10395, (Mouse) 50768, (Rat) 58834
neural tube closure
heart morphogenesis
signal transduction
negative regulation of cell proliferation
hindbrain morphogenesis
actin cytoskeleton organization
negative regulation of cell migration
forebrain development
regulation of Rho protein signal transduction
negative regulation of Rho protein signal transduction
intracellular signal transduction
focal adhesion assembly
regulation of small GTPase mediated signal transduction
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
positive regulation of execution phase of apoptosis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cytoskeleton organization
activation of phospholipase C activity
regulation of cell shape
regulation of actin cytoskeleton organization
positive regulation of protein dephosphorylation
positive regulation of GTPase activity
Rho protein signal transduction
cellular response to insulin stimulus
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